Efficacy of guar gum-based ronidazole capsules as a treatment for Tritrichomonas foetus infection in cats - EnvA - École nationale vétérinaire d'Alfort Accéder directement au contenu
Article Dans Une Revue Journal of Feline Medicine and Surgery Année : 2017

Efficacy of guar gum-based ronidazole capsules as a treatment for Tritrichomonas foetus infection in cats

Seyf Eddine Makhlouf
  • Fonction : Auteur
Loic Desquilbet
Fani Hovhannessian
  • Fonction : Auteur
Cassandre Boogaerts
  • Fonction : Auteur
Vanessa Dore
  • Fonction : Auteur
Myriam Anthony
  • Fonction : Auteur
Bernadette Espana
  • Fonction : Auteur
Caroline Prouillac
  • Fonction : Auteur
Plamen Kirilov
  • Fonction : Auteur
Bruno Polack

Résumé

Objectives The aims of the study were to determine the in vitro drug release of guar gum-coated capsules of ronidazole, and to evaluate the pharmacokinetics and efficacy of this formulation for the treatment of cats naturally infected with Tritrichomonas foetus. Methods The pharmacokinetics of ronidazole were evaluated in five healthy cats and five cats infected with T foetus. In a second step, the clinical efficacy of these capsules was evaluated by a controlled, randomised, double-blind clinical trial performed in 47 infected cats from French catteries. In this study, cats were randomly allocated to either the ronidazole treatment group (n = 25) or a placebo group (n = 22). Ronidazole (30 mg/kg) q24h for 14 days was administered to the treated cats. After 14 days of treatment, the presence of T foetus was tested by conventional PCR assay. Results In the pharmacokinetic study, a delayed peak plasma concentration was observed in healthy and infected cats, with no significant difference between these two groups (mean geometric mean of 9 h for time to maximum plasma concentration [T max ], 21.6 µg/ml for time to maximum plasma concentration [C max ] and 467.4 μg/h/ml for the area under the curve [AUC] in healthy cats; and 9.4 h for T max , 17.1 µg/ml for C max and 481 μg/h/ml for AUC in infected cats). In the clinical trial, T foetus was detected in 16% of cats from the treated group and 82% of cats from the placebo group at the end of the study ( P <0.001). No clinical signs of adverse drug reactions were observed. Conclusions and relevance Oral administration of guar gum-coated capsules of ronidazole at a dose of 30 mg/kg once daily for 14 days delays the peak plasma concentration and eradicates infection in most cases.

Dates et versions

hal-04017498 , version 1 (07-03-2023)

Identifiants

Citer

Aurélien Grellet, Seyf Eddine Makhlouf, Loic Desquilbet, Fani Hovhannessian, Cassandre Boogaerts, et al.. Efficacy of guar gum-based ronidazole capsules as a treatment for Tritrichomonas foetus infection in cats. Journal of Feline Medicine and Surgery, 2017, 19 (2), pp.177-184. ⟨10.1177/1098612X15621353⟩. ⟨hal-04017498⟩

Collections

ENVA
5 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More