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Article Dans Une Revue Journal of Clinical Medicine Année : 2022

Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years' Evolution Data on a 71-Patient Series

1 M2iSH - Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte
2 Service de Médecine Interne [CHU Clermont-Ferrand]
3 CHU Tenon [AP-HP]
4 CRESS (U1153 / UMR_A 1125) - Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques
5 Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
6 CHU Pitié-Salpêtrière [AP-HP]
7 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
8 Centre Léon Bérard [Lyon]
9 UB - Université de Bordeaux
10 Service de médecine interne et maladies infectieuses [Bordeaux]
11 Irset - Institut de recherche en santé, environnement et travail
12 Service de Médecine interne et immunologie clinique [Rennes] = internal medicine and clinical immunology [Rennes]
13 Hôpital Edouard Herriot [CHU - HCL]
14 CHU Nantes - Centre Hospitalier Universitaire de Nantes
15 Centre Hospitalier de Charleville-Mezières
16 UPD5 - Université Paris Descartes - Paris 5
17 Hôpital Louis Mourier - AP-HP [Colombes]
18 CHU Henri Mondor [Créteil]
19 CHU Bordeaux
20 BPH - Bordeaux population health
21 GHiGS - Global Health in the Global South
22 Centre de Référence du Sud Ouest des Maladies Rénales Rares
23 DYNAMIC - Dynamic Microbiology - EA 7380
24 CHU de la Martinique [Fort de France]
25 Centre Hospitalier de Dax
26 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
27 Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB)
28 Unité de Biostatistiques [CHU Clermont-Ferrand]
Camille Frances
  • Fonction : Auteur
  • PersonId : 941936
Jean-Charles Piette
  • Fonction : Auteur
  • PersonId : 934588
François Lifermann
  • Fonction : Auteur
  • PersonId : 955440

Résumé

Aseptic abscess (AA) syndrome is a rare type of inflammatory disorder involving polymorphonuclear neutrophils (PMNs), often associated with inflammatory bowel disease (IBD). This study sought to describe the clinical characteristics and evolution of this syndrome in a large cohort. We included all patients included in the French AA syndrome register from 1999 to 2020. All patients fulfilled the criteria outlined by Andre et al. in 2007. Seventy-one patients were included, 37 of which were men (52.1%), of a mean age of 34.5 +/- 17 years. The abscesses were located in the spleen (71.8%), lymph nodes (50.7%), skin (29.5%), liver (28.1%), lung (22.5), and rarer locations (brain, genitals, kidneys, ENT, muscles, or breasts). Of all the patients, 59% presented with an associated disease, primarily IBD (42%). They were treated with colchicine (28.1%), corticosteroids (85.9%), immunosuppressants (61.9%), and biologics (32.3%). A relapse was observed in 62% of cases, mostly in the same organ. Upon multivariate analysis, factors associated with the risk of relapse were: prescription of colchicine (HR 0.52; 95% CI [0.28-0.97]; p = 0.042), associated IBD (HR 0.57; 95% CI [0.32-0.99]; p = 0.047), and hepatic or skin abscesses at diagnosis (HR 2.14; 95% CI [1.35-3.40]; p = 0.001 and HR 1.78; 95% CI [1.07-2.93]; p = 0.024, respectively). No deaths occurred related to this disease. This large retrospective cohort study with long follow up showed that AA syndrome is a relapsing systemic disease that can evolve on its own or be the precursor of an underlying disease, such as IBD. Of all the available treatments, colchicine appeared to be protective against relapse.
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hal-03763425 , version 1 (29-08-2022)

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Ludovic Trefond, Camille Frances, Nathalie Costedoat-Chalumeau, Jean-Charles Piette, Julien Haroche, et al.. Aseptic Abscess Syndrome: Clinical Characteristics, Associated Diseases, and up to 30 Years' Evolution Data on a 71-Patient Series. Journal of Clinical Medicine, 2022, 11 (13), pp.1-10. ⟨10.3390/jcm11133669⟩. ⟨hal-03763425⟩
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